They know there are people out there resistant to COVID

This is a nice review of the bright side of mutations. The spike protein binds Angiotensin-Converting Enzyme 2 (ACE2) on its host cell's surface. It has undergone so many mutations that help it do that better while other mutations make it harder. Those strains die out quickly, if they're even noticed at all, because the virus can't break in, set up shop, and reproduce.

However, just like so many of the COVID mutations that the omicron variants have that don't break it, their host animals also have mutations that make something different without messing up its function. The article discusses one of the mutations that protect a person from contracting HIV as an example. There are some crummy conditions that people can have that also have the upside of making them susceptible to something else that is harmful. So now scientists are trying to sort through the genes of people like Ms. Kaoukaki who haven't caught COVID in spite of definitely being exposed.

Who knows? Their ACE2 proteins might just be different enough in the receptor-binding domain that the spike protein cannot latch on. That doesn't mean it can't still do its regular job. Ms. Kaoukaki didn't/doesn't have any antibodies for COVID so they know she didn't just have an asymptomatic infection or somehow tested with a false negative result. That means that COVID virii did not have the ability to stick around long enough for their immune systems to mount a response against them.

If you think you might be one of these people that never tested positive when you're certain you should have, give these folks a ring. Please.

Pete, I've been thinking about this lately.  Perhaps wishful thinking but I've been wondering if my family has some innate at least relative immunity.  First, I'm not aware of a single blood relative who has gotten it  and that includes not only immediate family members but also cousins and their kids etc.  More recently, my 89 yr old mother was at a card game.   Everyone else at the game got it, not her.  Plus she was exposed to another person with it in her household and still didn't get it (this was before her 2nd booster and long after the first one).   My adult kids live in Brooklyn.  Quite a few of the NYC area young adult children of my friends got it.  Not mine.  I don't know.  Still being careful.

Maybe it is worth giving the folks a call. It could mean something important to their efforts. One of the people is in New York City.

“We’re going to find the genetic and immunological determinants of the various severe forms of coronavirus infection.”

— Dr. Jean-Laurent Casanova, Co-Leader

The Rockefeller University, Howard Hughes Medical Institute (HHMI), New York, New York, USA

Jean-Laurent Casanova, MD, PhD

St. Giles Laboratory of Human Genetics of Infectious Diseases
The Rockefeller University & HHMI, New York, USA

Laboratory of Human Genetics of Infectious Diseases
Necker Hospital for Sick Children & INSERM, Paris, France

Tel: +1 (212) 327-7331

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